KEGG DRUG Database
(Example) D00109
KEGG DRUG is a chemical structure based information resource for all approved drugs in Japan and the U.S.A. Each chemical structure is identified by the D number, and is associated with generic names, trade names, efficacy, target information, etc. KEGG DRUG is maintained in the KEGG LIGAND relational database.
Drugs consisting of multiple components are subcategorized as follows.
- Mixture - Mixture of chemicals
- Crude - Crude drugs
- Formula - TCM (Traditional Chinese Medicine) formulas
Generic Names
The chemical structure of a drug is identified by the standardized generic name, but the names can be different in different countries or organizations. KEGG DRUG includes the following names.
- JAN - Japanese Approved Name
- USAN - United States Adopted Name
- NF - National Formulary drug name
- INN - International Nonproprietary Name
In addition, drugs listed in the pharmacopoeia are denoted by:
- JP15 - Japanese Pharmacopoeia, 15th edition
- USP - United States Pharmacopeia
which also imply the JAN and USAN names, respectively.
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Trade Names
Selected trade names (TNs) are also given. More names may be found from the outside link to DailyMed, which provides FDA approved labels (package inserts) information of marketed drugs. Labels information of Japanese drugs provided by JAPIC are maintained in the following Japanese language databases.
Classification System
Different drug classification systems are maintained as part of the KEGG BRITE functional hierarchies, such as the Anatomical Therapeutic Chemical (ATC) classification system.
Target Information
The drug-target relationship is not simply a molecule-molecule relationship. The target is given in the context of KEGG pathways, enabling the analysis of drugs as perturbants to the biological system. The BRITE files for drug classifications may be examined by adding the target information as follows.
History of Drug Development
KEGG DRUG structure maps graphically illustrate, in a manner similar to KEGG pathway maps, our knowledge on drug development. They are in the following category of the KEGG PATHWAY database.
The BRITE files for drug classifications may be examined by adding the structure map numbers as follows.
Other Documents
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