KEGG   PATHWAY: hsa04510Help
Entry
hsa04510                    Pathway                                
Name
Focal adhesion - Homo sapiens (human)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cell Communication
BRITE hierarchy
Pathway map
hsa04510  Focal adhesion
hsa04510

All organismsOrtholog table
Disease H00226  Glanzmann thrombasthenia
Drug D01029  Tirofiban hydrochloride (USAN)
D01977  Gefitinib (JAN/USAN/INN)
D02778  Abciximab (genetical recombination) (JAN)
D03065  Becaplermin (USAN/INN)
D03252  Bosutinib (USAN)
D03257  Trastuzumab (genetical recombination) (JAN)
D03297  Mecasermin (genetical recombination) (JAN)
D03350  Canertinib dihydrochloride (USAN)
D03658  Dasatinib (USAN)
D04023  Erlotinib hydrochloride (JAN/USAN)
D04024  Lapatinib tosilate hydrate (JAN)
D04870  Mecasermin rinfabate (USAN/INN)
D05399  Pelitinib (USAN/INN)
D05446  Pertuzumab (genetical recombination) (JAN)
D06407  Vandetanib (JAN/INN)
D06414  Dasatinib hydrate (JAN)
D06888  Eptifibatide (INN)
D07907  Erlotinib (INN)
D08108  Lapatinib (INN)
D08607  Tirofiban (INN)
D08950  Neratinib (INN/USAN)
Other DBs
GO: 0005925
Organism
Homo sapiens (human) [GN:hsa]
Gene
1277  COL1A1, OI4 [KO:K06236]
1278  COL1A2, OI4 [KO:K06236]
1280  COL2A1, ANFH, AOM, COL11A3, MGC131516, SEDC [KO:K06236]
1281  COL3A1, EDS4A, FLJ34534 [KO:K06236]
1289  COL5A1 [KO:K06236]
1290  COL5A2, MGC105115 [KO:K06236]
1301  COL11A1, CO11A1, COLL6, STL2 [KO:K06236]
1302  COL11A2, DFNA13, DFNB53, HKE5, PARP, STL3 [KO:K06236]
50509  COL5A3 [KO:K06236]
1282  COL4A1, arresten [KO:K06237]
1284  COL4A2, DKFZp686I14213, FLJ22259 [KO:K06237]
1286  COL4A4, CA44 [KO:K06237]
1288  COL4A6, MGC88184 [KO:K06237]
1291  COL6A1, OPLL [KO:K06238]
1292  COL6A2, DKFZp586E1322, FLJ46862, PP3610 [KO:K06238]
1293  COL6A3, DKFZp686D23123, DKFZp686K04147, DKFZp686N0262, FLJ34702, FLJ98399 [KO:K06238]
131873  COL6A6 [KO:K06238]
284217  LAMA1, LAMA [KO:K05637]
3908  LAMA2, LAMM [KO:K06239]
3909  LAMA3, BM600, E170, LAMNA, LOCS, lama3a [KO:K06240]
3910  LAMA4, DKFZp686D23145, LAMA3, LAMA4*-1 [KO:K06241]
3911  LAMA5, KIAA1907 [KO:K06242]
3912  LAMB1, CLM, MGC142015 [KO:K05636]
3913  LAMB2, LAMS [KO:K06243]
3914  LAMB3, BM600-125KDA, FLJ99565, LAM5, LAMNB1 [KO:K06244]
22798  LAMB4 [KO:K06245]
3915  LAMC1, LAMB2, MGC87297 [KO:K05635]
3918  LAMC2, B2T, BM600, CSF, EBR2, EBR2A, LAMB2T, LAMNB2, MGC138491, MGC141938 [KO:K06246]
10319  LAMC3, DKFZp434E202 [KO:K06247]
1101  CHAD, SLRR4A [KO:K06248]
5649  RELN, PRO1598, RL [KO:K06249] [EC:3.4.21.-]
1311  COMP, EDM1, EPD1, MED, MGC131819, MGC149768, PSACH, THBS5 [KO:K04659]
7057  THBS1, THBS, THBS-1, TSP, TSP-1, TSP1 [KO:K04659]
7058  THBS2, TSP2 [KO:K04659]
7059  THBS3, MGC119564, MGC119565, TSP3 [KO:K04659]
7060  THBS4, TSP4 [KO:K04659]
2335  FN1, CIG, DKFZp686F10164, DKFZp686H0342, DKFZp686I1370, DKFZp686O13149, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF [KO:K05717]
6696  SPP1, BNSP, BSPI, ETA-1, MGC110940, OPN [KO:K06250]
7448  VTN, V75, VN, VNT [KO:K06251]
3371  TNC, 150-225, GMEM, GP, HXB, JI, MGC167029, TN, TN-C [KO:K06252]
63923  TNN, TN-W [KO:K06252]
7143  TNR, MGC149328, TN-R [KO:K06252]
7148  TNXB, HXBL, TENX, TNX, TNXB1, TNXB2, TNXBS, XB, XBS [KO:K06252]
7450  VWF, F8VWF, VWD [KO:K03900]
3381  IBSP, BNSP, BSP, BSP-II, SP-II [KO:K06253]
3672  ITGA1, CD49a, VLA1 [KO:K06480]
3673  ITGA2, BR, CD49B, GPIa, VLA-2, VLAA2 [KO:K06481]
3674  ITGA2B, CD41, CD41B, GP2B, GPIIb, GTA, HPA3 [KO:K06476]
3675  ITGA3, CD49C, FLJ34631, FLJ34704, GAP-B3, GAPB3, MSK18, VCA-2, VL3A, VLA3a [KO:K06482]
3676  ITGA4, CD49D, IA4, MGC90518 [KO:K06483]
3678  ITGA5, CD49e, FNRA, VLA5A [KO:K06484]
3655  ITGA6, CD49f, DKFZp686J01244, FLJ18737, ITGA6B, VLA-6 [KO:K06485]
3679  ITGA7, FLJ25220 [KO:K06583]
8516  ITGA8 [KO:K06584]
3680  ITGA9, ALPHA-RLC, ITGA4L, RLC [KO:K06585]
8515  ITGA10, PRO827 [KO:K06586]
22801  ITGA11, HsT18964 [KO:K06587]
3685  ITGAV, CD51, DKFZp686A08142, MSK8, VNRA [KO:K06487]
3688  ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB [KO:K05719]
3690  ITGB3, CD61, GP3A, GPIIIa [KO:K06493]
3691  ITGB4, CD104 [KO:K06525]
3693  ITGB5, FLJ26658 [KO:K06588]
3694  ITGB6 [KO:K06589]
3695  ITGB7 [KO:K06590]
3696  ITGB8 [KO:K06591]
5154  PDGFA, PDGF-A, PDGF1 [KO:K04359]
5155  PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis [KO:K04359]
56034  PDGFC, FALLOTEIN, SCDGF [KO:K05450]
80310  PDGFD, IEGF, MGC26867, SCDGF-B, SCDGFB [KO:K05450]
1950  EGF, HOMG4, URG [KO:K04357]
3479  IGF1, IGF1A, IGFI [KO:K05459]
5228  PGF, D12S1900, PGFL, PLGF, PlGF-2, SHGC-10760 [KO:K05448]
7422  VEGFA, MGC70609, MVCD1, VEGF, VPF [KO:K05448]
7423  VEGFB, VEGFL, VRF [KO:K05448]
2277  FIGF, VEGF-D, VEGFD [KO:K05449]
7424  VEGFC, Flt4-L, VRP [KO:K05449]
3082  HGF, DFNB39, F-TCF, HGFB, HPTA, SF [KO:K05460]
5156  PDGFRA, CD140A, MGC74795, PDGFR2, RHEPDGFRA [KO:K04363] [EC:2.7.10.1]
5159  PDGFRB, CD140B, JTK12, PDGFR, PDGFR1 [KO:K05089] [EC:2.7.10.1]
3480  IGF1R, CD221, IGFIR, IGFR, JTK13, MGC142170, MGC142172, MGC18216 [KO:K05087] [EC:2.7.10.1]
3791  KDR, CD309, FLK1, VEGFR, VEGFR2 [KO:K05098] [EC:2.7.10.1]
1956  EGFR, ERBB, ERBB1, HER1, PIG61, mENA [KO:K04361] [EC:2.7.10.1]
2321  FLT1, FLT, VEGFR1 [KO:K05096] [EC:2.7.10.1]
2324  FLT4, FLT41, LMPH1A, PCL, VEGFR3 [KO:K05097] [EC:2.7.10.1]
4233  MET, AUTS9, HGFR, RCCP2, c-Met [KO:K05099] [EC:2.7.10.1]
2064  ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN_19, NEU, NGL, TKR1 [KO:K05083] [EC:2.7.10.1]
6714  SRC, ASV, SRC1, c-SRC, p60-Src [KO:K05704] [EC:2.7.10.2]
2909  GRLF1, ARHGAP35, GRF-1, KIAA1722, MGC10745, P190-A, P190A, p190ARhoGAP, p190RhoGAP [KO:K05732]
394  ARHGAP5, GFI2, RhoGAP5, p190-B, p190BRhoGAP [KO:K13709]
387  RHOA, ARH12, ARHA, RHO12, RHOH12 [KO:K04513]
1729  DIAPH1, DFNA1, DIA1, DRF1, FLJ25265, LFHL1, hDIA1 [KO:K05740]
6093  ROCK1, MGC131603, MGC43611, P160ROCK, PRO0435 [KO:K04514] [EC:2.7.11.1]
9475  ROCK2, KIAA0619 [KO:K04514] [EC:2.7.11.1]
4633  MYL2, CMH10, DKFZp779C0562, MLC2 [KO:K10351]
4636  MYL5 [KO:K12753]
58498  MYL7, MYL2A, MYLC2A [KO:K12754]
10398  MYL9, LC20, MGC3505, MLC2, MRLC1, MYRL2 [KO:K12755]
93408  MYL10, MYLC2PL, PLRLC [KO:K12756]
103910  MYL12B, MLC-B, MRLC2 [KO:K12757]
10627  MYL12A, MLCB, MRCL3, MRLC3, MYL2B [KO:K12757]
29895  MYLPF, DKFZp779C0757, HUMMLC2B, MGC13450, MRLC2, MYL11 [KO:K12758]
5499  PPP1CA, MGC15877, MGC1674, PP-1A, PP1alpha, PPP1A [KO:K06269] [EC:3.1.3.16]
5500  PPP1CB, MGC3672, PP-1B, PP1beta, PPP1CD [KO:K06269] [EC:3.1.3.16]
5501  PPP1CC, PP1gamma, PPP1G [KO:K06269] [EC:3.1.3.16]
4659  PPP1R12A, MBS, MGC133042, MYPT1 [KO:K06270]
4638  MYLK, DKFZp686I10125, FLJ12216, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK [KO:K00907] [EC:2.7.11.18]
85366  MYLK2, KMLC, MLCK, MLCK2, skMLCK [KO:K00907] [EC:2.7.11.18]
91807  MYLK3, MGC126319, MGC126320, MLCK, MLCK2, caMLCK [KO:K00907] [EC:2.7.11.18]
60  ACTB, PS1TP5BP1 [KO:K05692]
646048   [KO:K05692]
646821   [KO:K05692]
71  ACTG1, ACT, ACTG, DFNA20, DFNA26 [KO:K05692]
5923  RASGRF1, CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187 [KO:K04349]
824  CAPN2, CANP2, CANPL2, CANPml, FLJ39928, mCANP [KO:K03853] [EC:3.4.22.53]
81  ACTN4, ACTININ-4, DKFZp686K23158, FSGS, FSGS1 [KO:K05699]
87  ACTN1, FLJ40884, FLJ54432 [KO:K05699]
88  ACTN2, CMD1AA [KO:K05699]
89  ACTN3, MGC117002, MGC117005 [KO:K05699]
7094  TLN1, ILWEQ, KIAA1027, TLN [KO:K06271]
83660  TLN2, DKFZp451B1011, DKFZp686I0976, DKFZp686K0979, ILWEQ, KIAA0320 [KO:K06271]
2316  FLNA, ABP-280, ABPX, DKFZp434P031, FLN, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2 [KO:K04437]
2317  FLNB, ABP-278, ABP-280, AOI, DKFZp686A1668, DKFZp686O033, FH1, FLN1L, LRS1, SCT, TABP, TAP [KO:K04437]
2318  FLNC, ABP-280, ABP280A, ABPA, ABPL, FLJ10186, FLN2 [KO:K04437]
5829  PXN, FLJ16691 [KO:K05760]
3611  ILK, DKFZp686F1765, ILK-2, P59 [KO:K06272] [EC:2.7.11.1]
7791  ZYX, ESP-2, HED-2 [KO:K06273]
7408  VASP [KO:K06274]
7414  VCL, CMD1W, CMH15, MVCL [KO:K05700]
29780  PARVB, CGI-56 [KO:K06275]
55742  PARVA, FLJ10793, FLJ12254, MXRA2 [KO:K06275]
64098  PARVG [KO:K06275]
5170  PDPK1, MGC20087, MGC35290, PDK1, PRO0461 [KO:K06276] [EC:2.7.11.1]
10000  AKT3, DKFZp434N0250, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2 [KO:K04456] [EC:2.7.11.1]
207  AKT1, AKT, MGC99656, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA [KO:K04456] [EC:2.7.11.1]
208  AKT2, PKBB, PKBBETA, PRKBB, RAC-BETA [KO:K04456] [EC:2.7.11.1]
2932  GSK3B [KO:K03083] [EC:2.7.11.26]
1499  CTNNB1, CTNNB, DKFZp686D02253, FLJ25606, FLJ37923 [KO:K02105]
5578  PRKCA, AAG6, MGC129900, MGC129901, PKC-alpha, PKCA, PRKACA [KO:K02677] [EC:2.7.11.13]
5579  PRKCB, MGC41878, PKC-beta, PKCB, PRKCB1, PRKCB2 [KO:K02677] [EC:2.7.11.13]
5582  PRKCG, MGC57564, PKC-gamma, PKCC, PKCG, SCA14 [KO:K02677] [EC:2.7.11.13]
5747  PTK2, FADK, FAK, FAK1, FRNK, pp125FAK [KO:K05725] [EC:2.7.10.2]
5290  PIK3CA, MGC142161, MGC142163, PI3K, p110-alpha [KO:K00922] [EC:2.7.1.153]
5291  PIK3CB, DKFZp779K1237, MGC133043, P110BETA, PI3K, PI3KBETA, PIK3C1 [KO:K00922] [EC:2.7.1.153]
5293  PIK3CD, P110DELTA, PI3K, p110D [KO:K00922] [EC:2.7.1.153]
5294  PIK3CG, PI3CG, PI3K, PI3Kgamma, PIK3 [KO:K00922] [EC:2.7.1.153]
23533  PIK3R5, F730038I15Rik, FOAP-2, P101-PI3K, p101 [KO:K02649]
5295  PIK3R1, GRB1, p85, p85-ALPHA [KO:K02649]
5296  PIK3R2, P85B, p85, p85-BETA [KO:K02649]
8503  PIK3R3, DKFZp686P05226, FLJ41892, p55, p55-GAMMA [KO:K02649]
5728  PTEN, 10q23del, BZS, DEC, GLM2, MGC11227, MHAM, MMAC1, PTEN1, TEP1 [KO:K01110] [EC:3.1.3.67]
10451  VAV3, FLJ40431 [KO:K05730]
7409  VAV1, VAV [KO:K05730]
7410  VAV2 [KO:K05730]
5879  RAC1, MGC111543, TC-25, p21-Rac1 [KO:K04392]
5880  RAC2, EN-7, Gx, HSPC022 [KO:K07860]
5881  RAC3 [KO:K07861]
5058  PAK1, MGC130000, MGC130001, PAKalpha [KO:K04409] [EC:2.7.11.1]
5062  PAK2, PAK65, PAKgamma [KO:K04410] [EC:2.7.11.1]
5063  PAK3, CDKN1A, MRX30, MRX47, OPHN3, PAK3beta, bPAK, hPAK3 [KO:K05733] [EC:2.7.11.1]
10298  PAK4 [KO:K05734] [EC:2.7.11.1]
56924  PAK6, PAK5 [KO:K05735] [EC:2.7.11.1]
57144  PAK7, KIAA1264, MGC26232, PAK5 [KO:K05736] [EC:2.7.11.1]
998  CDC42, CDC42Hs, G25K [KO:K04393]
9564  BCAR1, CAS, CAS1, CASS1, CRKAS, FLJ12176, FLJ45059, P130Cas [KO:K05726]
1398  CRK, CRKII [KO:K04438]
1399  CRKL [KO:K04438]
1793  DOCK1, DOCK180, ced5 [KO:K13708]
2889  RAPGEF1, C3G, DKFZp781P1719, GRF2 [KO:K06277]
5906  RAP1A, KREV-1, KREV1, RAP1, SMGP21 [KO:K04353]
5908  RAP1B, DKFZp586H0723, K-REV, RAL1B [KO:K07836]
5599  MAPK8, JNK, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1 [KO:K04440] [EC:2.7.11.24]
5601  MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, p54a, p54aSAPK [KO:K04440] [EC:2.7.11.24]
5602  MAPK10, FLJ12099, FLJ33785, JNK3, JNK3A, MGC50974, PRKM10, p493F12, p54bSAPK [KO:K04440] [EC:2.7.11.24]
3725  JUN, AP-1, AP1, c-Jun [KO:K04448]
673  BRAF, B-RAF1, BRAF1, FLJ95109, MGC126806, MGC138284, RAFB1 [KO:K04365] [EC:2.7.11.1]
857  CAV1, BSCL3, CGL3, MSTP085, VIP21 [KO:K06278]
858  CAV2, CAV, MGC12294 [KO:K12958]
859  CAV3, LGMD1C, LQT9, MGC126100, MGC126101, MGC126129, VIP-21, VIP21 [KO:K12959]
2534  FYN, MGC45350, SLK, SYN [KO:K05703] [EC:2.7.10.2]
25759  SHC2, SCK, SHCB, SLI [KO:K06279]
399694  SHC4, MGC34023, RaLP, SHCD [KO:K06279]
53358  SHC3, N-Shc, NSHC, RAI, SHCC [KO:K06279]
6464  SHC1, FLJ26504, SHC, SHCA [KO:K06279]
2885  GRB2, ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2 [KO:K04364]
6654  SOS1, GF1, GGF1, GINGF, HGF, NS4 [KO:K03099]
6655  SOS2, FLJ25596 [KO:K03099]
3265  HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1 [KO:K02833]
5894  RAF1, CRAF, NS5, Raf-1, c-Raf [KO:K04366] [EC:2.7.11.1]
5604  MAP2K1, MAPKK1, MEK1, MKK1, PRKMK1 [KO:K04368] [EC:2.7.12.2]
5594  MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk [KO:K04371] [EC:2.7.11.24]
5595  MAPK3, ERK1, HS44KDAP, HUMKER1A, MGC20180, P44ERK1, P44MAPK, PRKM3 [KO:K04371] [EC:2.7.11.24]
2002  ELK1 [KO:K04375]
595  CCND1, BCL1, D11S287E, PRAD1, U21B31 [KO:K04503]
894  CCND2, KIAK0002, MGC102758 [KO:K10151]
896  CCND3 [KO:K10152]
329  BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 [KO:K04725]
330  BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 [KO:K04725]
331  XIAP, API3, BIRC4, ILP1, MIHA, XLP2 [KO:K04725]
572  BAD, BBC2, BCL2L8 [KO:K02158]
596  BCL2, Bcl-2 [KO:K02161]
23396  PIP5K1C, KIAA0589, LCCS3, PIP5K-GAMMA, PIP5Kgamma, PIPKIg_v4 [KO:K00889] [EC:2.7.1.68]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference PMID:14756624
  Authors Berman AE, Kozlova NI, Morozevich GE.
  Title Integrins: structure and signaling.
  Journal Biochemistry (Mosc) 68:1284-99 (2003)
Reference PMID:15179030
  Authors Lee JW, Juliano R.
  Title Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal Mol Cells 17:188-202 (2004)
Reference PMID:11573199
  Authors Danen EH, Yamada KM.
  Title Fibronectin, integrins, and growth control.
  Journal J Cell Physiol 189:1-13 (2001)
Reference PMID:15459662
  Authors Guo W, Giancotti FG.
  Title Integrin signalling during tumour progression.
  Journal Nat Rev Mol Cell Biol 5:816-26 (2004)
Reference PMID:11229600
  Authors Petit V, Thiery JP.
  Title Focal adhesions: structure and dynamics.
  Journal Biol Cell 92:477-94 (2000)
Reference PMID:12235283
  Authors Stupack DG, Cheresh DA.
  Title Get a ligand, get a life: integrins, signaling and cell survival.
  Journal J Cell Sci 115:3729-38 (2002)
Reference PMID:12640026
  Authors Parsons JT.
  Title Focal adhesion kinase: the first ten years.
  Journal J Cell Sci 116:1409-16 (2003)
Reference PMID:15688067
  Authors Mitra SK, Hanson DA, Schlaepfer DD.
  Title Focal adhesion kinase: in command and control of cell motility.
  Journal Nat Rev Mol Cell Biol 6:56-68 (2005)
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  Authors Comoglio PM, Boccaccio C, Trusolino L.
  Title Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal Curr Opin Cell Biol 15:565-71 (2003)
Reference PMID:15108811
  Authors Schlaepfer DD, Mitra SK.
  Title Multiple connections link FAK to cell motility and invasion.
  Journal Curr Opin Genet Dev 14:92-101 (2004)
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  Authors Burridge K, Wennerberg K.
  Title Rho and Rac take center stage.
  Journal Cell 116:167-79 (2004)
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  Authors Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title Rho GTPases: signaling, migration, and invasion.
  Journal Exp Cell Res 261:1-12 (2000)
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  Authors Vanhaesebroeck B, Alessi DR.
  Title The PI3K-PDK1 connection: more than just a road to PKB.
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  Authors Nicholson KM, Anderson NG.
  Title The protein kinase B/Akt signalling pathway in human malignancy.
  Journal Cell Signal 14:381-95 (2002)
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  Title Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
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  Authors Turner CE.
  Title Paxillin and focal adhesion signalling.
  Journal Nat Cell Biol 2:E231-6 (2000)
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  Title The mechanism of action of the tumour suppressor gene PTEN.
  Journal Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04070  Phosphatidylinositol signaling system
hsa04110  Cell cycle
hsa04210  Apoptosis
hsa04310  Wnt signaling pathway
hsa04512  ECM-receptor interaction
hsa04810  Regulation of actin cytoskeleton
KO pathway ko04510
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